SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.
IC50&Target
SIRT1
0.205 μM (IC50)
SIRT2
11.5 μM (IC50)
SIRT3
>100 μM (IC50)
体外研究
SIRT1-IN-1 (compound 2) has little effect on SIRT3 (IC50>100 μM) and HDAC (IC50>100 μM).
分子式
C14H16N2O
分子量
228.29
CAS号
352554-02-0
运输条件
Room temperature in continental US; may vary elsewhere.