C-176 is a strong and covalent mouse STING inhibitor.
体外研究
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
体内研究
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 mice.
Animal Model:
WT type mice.
Dosage:
750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:
Intraperitoneally, once.
Result:
Significantly reduced Serum levels of type I IFNs and IL-6.
分子式
C11H7In2O4
分子量
358.09
CAS号
314054-00-7
运输条件
Room temperature in continental US; may vary elsewhere.