JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R.
体内研究
JNJ-10397049 (10-30 mg/kg) decreases the latency for persistent sleep and increased nonrapid eye movement and rapid eye movement sleep time.
JNJ-10397049 blocks ethanol self-administration, place preference and reinstatement.
Animal Model:
Male Sprague-Dawley rats.
Dosage:
10 mg/kg.
Administration:
Subcutaneous administration.
Result:
Induced a significant reduction in NREM sleep latency and an increase in NREM sleep duration during the first 2 h after administration relative to vehicle treatment.
分子式
C19H20N2O3Br2
分子量
484.18
CAS号
708275-58-5
运输条件
Room temperature in continental US; may vary elsewhere.