Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
IC50&Target
DPP4
体内研究
Dutogliptin exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. Dutogliptin is metabolically stable and does not inhibit or induce the activity of major CYP450s.
分子式
C10H20BN3O3
分子量
241.10
CAS号
852329-66-9
中文名称
杜拓格利普汀
运输条件
Room temperature in continental US; may vary elsewhere.