HBX 41108 (Synonyms:7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈;HBX 41108 抑制剂)
目录号 : KCM15769 CAS No. : 924296-39-9 纯度 : ≥95%
HBX 41108 is an uncompetitive, reversible inhibitor of ubiquitin-specific protease 7 (USP7) activity (IC = 424 nM). It dose-dependently inhibits USP7-mediated p53 deubiquitination in a cell-free assay, with an IC value of approximately 0.8 µM, as well as in HEK293 cells. It is selective for USP7 over a panel of proteases including aspartic, serine, and metalloproteases (ICs = >10 µM), several cysteine proteases (ICs = >1 and >10 µM), and the deubiquitinating enzymes UCH-L1 (IC = >1 µM) and SENP1 (IC = >10 µM). HBX 41108 increases the levels of p53 and p21/WAF1, a p53 target gene. It also dose-dependently inhibits proliferation of HCT116 cells with an IC value of approximately 1 µM and induces apoptosis.
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分子式
C13H3ClN4O
分子量
266.6
CAS号
924296-39-9
中文名称
HBX 41108 抑制剂
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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