KKL 顾客使用本产品发表的 4 篇科研文献

Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (K_i=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.

Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED₅₀ of 0.033 mg/kg in Wessler model.

Room temperature in continental US; may vary elsewhere.

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