Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
IC50&Target
AMPK
体外研究
Ampkinone stimulates the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake inmuscle cells.
体内研究
Ampkinone-treated DIO mice significantly reduce total body weight and overall fat mass. Histological examination and measurement of lipid parameters show that Ampkinone effectively improves metabolic abnormalities in the DIO mice model.
分子式
C31H23NO6
分子量
505.52
CAS号
1233082-79-5
运输条件
Room temperature in continental US; may vary elsewhere.