L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
IC50&Target
Ki: 26 nM (NPY5-R).
体外研究
L 152804 displays > 300-fold selectivity over hY1, hY2, and hY4 receptors.
分子式
C23H26O4
分子量
366.45
CAS号
6508-43-6
运输条件
Room temperature in continental US; may vary elsewhere.