AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
IC50&Target
Protease-activated receptor-2 (IC50= 23 nM)
体外研究
Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling.
分子式
C30H27BrN4O3
分子量
571.46
CAS号
2100284-59-9
运输条件
Room temperature in continental US; may vary elsewhere.