17-phenyl trinor Prostaglandin F2α isopropyl ester - CAS:130209-76-6

您当前的位置：

17-phenyl trinor Prostaglandin F2α isopropyl ester (Synonyms:比马前列素异丙酯;比马前列腺素异丙酯)

目录号 : KCM10964 CAS No. : 130209-76-6 纯度 : ≥98%

Data Sheet 产品使用指南

17-phenyl trinor PGF N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.

规格	价格	是否有货	数量
10 mM * 1 mL in DMSO		In-stock
1mg		In-stock
5mg		In-stock
10mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

PPACK dihydrochloride In-stock
PPACK TFA In-stock
Isoprenaline In-stock
Naloxone In-stock
Davidigenin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma.

体内研究

17 Phenyl trinor PGF2 α isopropyl ester (3 μg; single ocular local administration) can induce a statistically significant maximum 2.9 mmHg IOP reduction in cynomolgus monkeys with normal blood pressure [1].
17-Phenyl trinor PGF2 α isopropyl ester (3 μg; ocular surface administration; A single dose can cause mild eye irritation in domestic female cats.
17-Phenyl trinor PGF2α isopropyl ester (0.03-3 μg; Single ocular administration can induce dose-dependent mild conjunctival congestion in New Zealand albino white rabbits [1].

Animal Model:	Cynomolgus monkeys
Dosage:	3 μg
Administration:	o.a.; single dose
Result:	Produced a maximum reduction in IOP of 2.9 mmHg.

Animal Model:	Domestic female cats (2-3 kg)
Dosage:	3 μg
Administration:	o.a.; single dose
Result:	Caused a maximum irritation score of 0.2 arbitrary units, which was significantly lower than the irritation induced by PGF2α isopropyl ester (1b).

Animal Model:	New Zealand White albino rabbits (2-3 kg)
Dosage:	0.03 μg, 0.1 μg, 0.3 μg, 1 μg, 3 μg
Administration:	o.a.; single dose
Result:	Induced mild conjunctival hyperemia, with maximum difference scores (experimental eye vs. control eye) of approximately 0.8, 1.0, 1.4, 1.5, and 1.7 arbitrary units at doses of 0.03 μg, 0.1 μg, 0.3 μg, 1 μg, and 3 μg, respectively; this hyperemia was significantly less pronounced than that induced by PGF2α isopropyl ester (1b).

分子式

C₂₆H₃₈O₅

分子量

430.6

CAS号

130209-76-6

中文名称

比马前列素异丙酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (232.24 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3224 mL	11.6122 mL	23.2245 mL
5 mM	0.4645 mL	2.3224 mL	4.6449 mL
10 mM	0.2322 mL	1.1612 mL	2.3224 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

[1]. Resul B, et al. Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. J Med Chem. 1993;36(2):243-248.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器