CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
体外研究
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR.
体内研究
CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%).
分子式
C24H22Cl2N6O3
分子量
513.38
CAS号
717899-97-3
运输条件
Room temperature in continental US; may vary elsewhere.