PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.
IC50&Target
PI4KIIIβ
3.6 nM (IC50)
PI4KIIIα
3 μM (IC50)
PI3Kδ
720 nM (IC50)
PI3KC2γ
1 μM (IC50)
PI3Kα
10 μM (IC50)
PI3Kγ
20 μM (IC50)
体外研究
PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ.
分子式
C22H25N3O5S2
分子量
475.58
CAS号
1881233-39-1
运输条件
Room temperature in continental US; may vary elsewhere.