JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]
Target: MAGL inhibitor
JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
分子式
C21H20F6N2O3
分子量
462.39
CAS号
1416133-89-5
运输条件
Room temperature in continental US; may vary elsewhere.