Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease.
IC50&Target
IC50: 2 nM (FLAP).
体外研究
Atuliflapon demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h.
Atuliflapon exhibits an IC50 of 39 nM for LTB4.
体内研究
Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively.
分子式
C24H26N6O3
分子量
446.50
CAS号
2041075-86-7
运输条件
Room temperature in continental US; may vary elsewhere.