AC-262536 是一种选择性的非甾体雄激素受体调节剂 (SARM)，具有有益的合成代谢作用。AC-262536 对雄激素受体具有强效激动剂活性，亲和力在低纳摩尔范围 (1-10 nM)。
| 生物活性 |
AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM). |
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| 体外研究 |
AC-262536 dose-dependently inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP. The effects are significant with 100 nM AC-262536 (%inhibition 47.2±12.2), and reaches a plateau with 1 μM treatment (%inhibition 50.7±7.6). Thus, AC-262536 can act as a functional antagonist in prostate cells. |
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| 体内研究 |
AC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike in castrated rats.
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| 分子式 |
C18H18N2O
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| 分子量 |
278.35
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| CAS号 |
870888-46-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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