Purpurogallin - CAS:569-77-7

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Purpurogallin (Synonyms:红倍酚)

目录号 : KM2824 CAS No. : 569-77-7 纯度 : 95%

Data Sheet 产品使用指南

Purpurogallin 是从栎属植物中提取的天然酚，具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性，其 IC₅₀ 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。

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生物活性

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC₅₀ of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.

体外研究

Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.

RT-PCR

Cell Line:	BV2 murine microglial cells
Concentration:	50 or 100 µM
Incubation Time:	7 or 25 hours
Result:	Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression.

Western Blot Analysis

Cell Line:	BV2 murine microglial cells
Concentration:	100 µM
Incubation Time:	75 minutes, 90 minutes, 120 minutes
Result:	Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways.

体内研究

Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.

Animal Model:	Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH)
Dosage:	100 μg/kg, 200 μg/kg, 400 μg/kg
Administration:	Intraperitoneal injection; for 48 or 72 hours
Result:	Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.

分子式

C₁₁H₈O₅

分子量

220.18

CAS号

569-77-7

中文名称

红倍酚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL (567.72 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.5417 mL	22.7087 mL	45.4174 mL
5 mM	0.9083 mL	4.5417 mL	9.0835 mL
10 mM	0.4542 mL	2.2709 mL	4.5417 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (9.45 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (9.45 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (9.45 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (9.45 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。