AR-C102222 hydrochloride - CAS:1781934-50-6

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AR-C102222 hydrochloride

目录号 : KM2819 CAS No. : 1781934-50-6 纯度 : ≥98%

Data Sheet 产品使用指南

AR-C102222 hydrochloride 是一种有效的、竞争性的、有口服活性的、高度选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC₅₀ 值为 37 nM。AR-C102222 hydrochloride 具有抗伤害和抗炎活性。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.

体内研究

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity.
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model.

Animal Model:	Male Balb/c mice (20-25 g).
Dosage:	3, 10, 30, 100 mg/kg.
Administration:	P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result:	Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.

分子式

C₁₉H₁₇ClF₂N₆O

分子量

418.83

CAS号

1781934-50-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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