TC-MCH 7c - CAS:864756-35-4

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TC-MCH 7c

目录号 : KM2783 CAS No. : 864756-35-4 纯度 : 98%

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TC-MCH 7c 是一种苯基吡啶酮衍生物，一种口服有效的，选择性的且可穿透血脑屏障的 MCH₁R 拮抗剂，对 hMCH₁R 的 IC₅₀ 为 5.6 nM。TC-MCH 7c 对人和小鼠 MCH₁R 的 K_i 分别为 3.4 nM 和 3.0 nM。

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生物活性

TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH₁R antagonist with an IC₅₀ of 5.6 nM for hMCH₁R. TC-MCH 7c has K_is of 3.4 nM and 3.0 nM of human and mouse MCH₁R, respectively.

体外研究

TC-MCH 7c has an IC₅₀ of 9.7 μM for MCH₁R in [Ca]i mobilization.
TC-MCH 7c has IC₅₀s of 23 nM and 9.0 μM for FLIPR and hERG, respectively.

体内研究

TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model.
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively.

Animal Model:	C57BL/6J DIO mice
Dosage:	3, 10 and 30 mg/kg
Administration:	Oral; once-daily for 1.5 months
Result:	Exhibited excellent body weight reduction in a dose-dependent manner.

Animal Model:	Diet-induced obesity mice
Dosage:	3, 10 and 30 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral
Result:	Plasma concentrations at 2, 15, and 24 hours were 5.1, 1.8, and 0.7 μM, respectively.

分子式

C₂₄H₂₅FN₂O₃

分子量

408.47

CAS号

864756-35-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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