Nitecapone (OR-462) 是一个短效的、具有口服活性的、儿茶酚-O-甲基转移酶 (COMT) 的抑制剂，具有胃肠道保护和抗氧化活性。Nitecapone (OR-462) 可清除活性氧和一氧化氮，防止脂质过氧化。
| 生物活性 |
Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation. |
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| 体外研究 |
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROOby 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%. |
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| 体内研究 |
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats.
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| 分子式 |
C12H11NO6
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| 分子量 |
265.22
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| CAS号 |
116313-94-1
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| 中文名称 |
硝替卡朋
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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