BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.
体外研究
HT-22 cells shows reduction of cell viability around 4.5 h after Glutamate (3 mM and 5 mM) treatment. BI-6c9 (10 μM; 18 hours) significantly attenuates the loss of cell viability after Glutamate excitotoxicity.
Cell Viability Assay
Cell Line:
HT-22 cells
Concentration:
10 μM
Incubation Time:
18 hours
Result:
Attenuated Glutamate-induced cell death.
分子式
C23H25N3O4S2
分子量
471.59
CAS号
791835-21-7
运输条件
Room temperature in continental US; may vary elsewhere.