AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors.
IC50&Target
Ki: 1.7 nM (A2AR)
体外研究
In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively.
分子式
C15H11ClFN5
分子量
315.73
CAS号
1321514-06-0
运输条件
Room temperature in continental US; may vary elsewhere.