DS-1040 Tosylate (0.0005-0.5 mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005 mg/kg and greater.
DS1040 (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg; i.v.) increases plasma D-dimer levels in a dose-dependent manner in the microthrombosis model. ED50 and EDmax are 122 and 221 nmol/L, respectively.
DS-1040 (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; orally) also increases plasma D-dimer levels. EC50 and ECmax values are 114 and 231 nmol/L, respectively.
| Animal Model: |
Male Slc:Wistar rats |
| Dosage: |
0.0005, 0.005, 0.05, 0.5 mg/kg |
| Administration: |
IV |
| Result: |
Significantly reduced the microthrombi index at doses of 0.005 mg/kg and greater.
|