Serotonin 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂，其 Ki 值为 44 μM。
| 生物活性 |
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. |
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| 体外研究 |
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin decreases the reaction velocity of COMT. |
| 体内研究 |
Serotonin produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13 mice receiving Serotonin compare to IL-13 receiving vehicle following induction of DSS colitis.
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| 分子式 |
C10H12N2O
|
| 分子量 |
176.22
|
| CAS号 |
50-67-9
|
| 中文名称 |
5-羟色胺；血清胺
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 科研文献 |
纯度： 98%
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