(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
IC50&Target
nAChR
体外研究
(+)-Sparteine (2 μM) (sulfate pentahydrate) reduces the ACh-induced current caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials of -50 mV to +30 mV, whereas its blocking effect increased at more negative membrane potentials. (+)-sparteine (5 μM and 10 μM) (sulfate pentahydrate) reduces the amplitude of the excitatory postsynaptic currents (EPSC) and the time constant of the EPSC decay.
运输条件
Room temperature in continental US; may vary elsewhere.