Gap19 TFA - KKL Med Inc.

您当前的位置：

Gap19 TFA

目录号 : KM19282 纯度 : 95%

Data Sheet 产品使用指南

Gap19 TFA 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 TFA 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 TFA 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 TFA 对心肌具有保护作用。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

(Tyr0)-Urocortin, rat In-stock
Stressin I In-stock
Suc-AAA-pNA In-stock
Perfluoropolyether carboxylic acid In-stock
Ala-D-γ-Glu-Lys-D-Ala-D-Ala In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.

体外研究

Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake.
Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells.
Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes.
Gap19 TFA (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.

体内研究

Gap19 TFA (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.

Animal Model:	C57/BL6 mice
Dosage:	25 mg/kg
Administration:	IV; 10 min before ligation
Result:	Significantly reduced the infarct size by approximately one-fifth.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (78.40 mM; Need ultrasonic)

H₂O : 100 mg/mL (78.40 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.7840 mL	3.9202 mL	7.8403 mL
5 mM	0.1568 mL	0.7840 mL	1.5681 mL
10 mM	0.0784 mL	0.3920 mL	0.7840 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 95%