GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption.
GSK2795039 reduces apoptosis.
体外研究
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis
Cell Line:
PC12 cells
Concentration:
25 μM
Incubation Time:
24 hours
Result:
Reduced apoptosis among PC12 cells.
体内研究
GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.
Animal Model:
C57BL6 mice
Dosage:
100 mg/kg
Administration:
Intraperitoneal injection; 100 mg/kg; 1 hour before
Result:
Caused 50% reduction in the level of serum amylase activity.
分子式
C23H26N6O2S
分子量
450.56
CAS号
1415925-18-6
运输条件
Room temperature in continental US; may vary elsewhere.