BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
IC50&Target
human PI4KIIIβ
80 nM (IC50)
Plasmodium PI4KIIIβ
3.5 nM (IC50)
体外研究
Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PH to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines.
分子量
352.39
CAS号
1513879-21-4
运输条件
Room temperature in continental US; may vary elsewhere.