Ioversol (MP-328) is a nonionic iodinated contrast medium (CM) that is used during a CT scan or x-ray in animal experiment. Ioversol does not damage the blood-brain barrier (BBB) in animal.
体外研究
Ioversol (100 mg iodine/ml) exposure induces significantly increased lactate dehydrogenase release and decreased 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide conversion in NRK-52E cells. Ioversol significantly increases apoptosis and caspase-3 protein expression in the NRK-52E cells. Ioversol treatment induces a significant increase in [Ca]i and intracellular ROS.
体内研究
In comparison with iothalamate, Ioversol has a greatly reduced propensity to stimulate the release of endothelin, from cultured cells and when injected into anesthetized rats. Ioversol produces less renal vasoconstriction than does iothalamate, in control and in USIC rats, and the development of radiocontrast nephropathy, assessed by creatinine clearance and morphologic damage to the renal medulla, is largely avoided.
分子式
C18H24N3O9I3
分子量
807.11
CAS号
87771-40-2
中文名称
碘佛醇;碘维索尔;伊奥索;碘氟醇
运输条件
Room temperature in continental US; may vary elsewhere.