Bupropion hydrochloride - CAS:31677-93-7

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Bupropion hydrochloride (Synonyms:Amfebutamone hydrochloride)

目录号 : KM18456 CAS No. : 31677-93-7 纯度 : 98%

Data Sheet 产品使用指南

Bupropion (Amfebutamone) hydrochloride 是一种典型的氨基酮类抗抑郁药，在结构上与Cathinone 有关。Bupropion hydrochloride 主要通过抑制多巴胺和去甲肾上腺素的再摄取以及阻断几种烟碱受体发挥作用。Bupropion hydrochloride 可用于抑郁症和戒烟。

规格	价格	是否有货
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Bupropion hydrochloride is an atypical antidepressant of the aminoketone group, structurally related to cathinone, associated with a wide interindividual variability. Bupropion hydrochloride exerts its effects mainly by inhibiting dopamine and norepinephrine reuptake and by blocking several nicotinic receptors. Bupropion hydrochloride can be used for the depression and smoking cessation.

体内研究

Bupropion (10, 15, 20 and 40 mg/kg., i.p.; Male albino mice weighing between 22–30 g) hydrochloride dose-dependently decreases immobility period (in seconds) with respect to vehicle control group. ED₅₀ values of bupropion in reducing the immobility period was found to be 18.5 and 18 mg/kg i.p., in forced swim test and tail suspension test, respectively. Bupropion (10, 20 and 40 mg/kg., i.p.) hydrochloride dose-dependently increases the concentration of free dopamine and its metabolite homovanillic acid in the mouse brain.
Bupropion hydrochloride possesses antidepressant activities in different animal models of depression through its dopaminergic and/or by modulating the L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway.

分子式

C₁₃H₁₈NOCl^.HCl

分子量

276.20

CAS号

31677-93-7

中文名称

盐酸安非他酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : ≥ 29 mg/mL (105.00 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6206 mL	18.1028 mL	36.2056 mL
5 mM	0.7241 mL	3.6206 mL	7.2411 mL
10 mM	0.3621 mL	1.8103 mL	3.6206 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%