Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
IC50&Target
Human Endogenous Metabolite
体外研究
Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na/H exchanger 1 induced by platelet-derived growth factor.
体内研究
Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
分子式
C22H28O3
分子量
340.46
CAS号
976-71-6
运输条件
Room temperature in continental US; may vary elsewhere.