Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2.
IC50&Target
SIRT1
体外研究
Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1.
Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1.
Cell Viability Assay
Cell Line:
BV2 microglia cells
Concentration:
0~15 µM
Incubation Time:
24 hours
Result:
Had no significant effect on cell survival.
Western Blot Analysis
Cell Line:
BV2 microglia cells
Concentration:
0~15 µM
Incubation Time:
1 hour
Result:
Inhibited the phosphorylation of IκBα, p65, but enhanced the expression of Nrf2 and HO-1.
分子式
C36H36N2O8
分子量
624.68
CAS号
163136-19-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.