Cannabisin F
目录号 : KM18255 CAS No. : 163136-19-4 纯度 : 98%

Cannabisin F 是一种 SIRT1 调制器。Cannabisin F 作为大麻籽木素酰胺,可用于抗炎、抗氧化研究。Cannabisin F 作为SIRT1/NF-κB 和 Nrf2 的调节因子,可能是一种潜在的神经退行性疾病的调节剂。

规格 价格 是否有货 数量
1mg
In-stock

Other Forms of Rapamycin:

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生物活性

Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2.

IC50&Target

SIRT1

体外研究

Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1.
Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1.

Cell Viability Assay

Cell Line: BV2 microglia cells
Concentration: 0~15 µM
Incubation Time: 24 hours
Result: Had no significant effect on cell survival.

Western Blot Analysis

Cell Line: BV2 microglia cells
Concentration: 0~15 µM
Incubation Time: 1 hour
Result: Inhibited the phosphorylation of IκBα, p65, but enhanced the expression of Nrf2 and HO-1.
分子式
C36H36N2O8
分子量
624.68
CAS号
163136-19-4
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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