Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.
IC50 value:
Target: Autophagy inducer
in vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1].
in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].
分子式
C22H28N2O4
分子量
384.47
CAS号
17391-18-3
中文名称
柯诺辛碱 B
运输条件
Room temperature in continental US; may vary elsewhere.