IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.
IC50 value: 1.01 uM (CHO-CFTR FLIPR) [1]
Target: CFTR
Profiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (cholera
toxin), up to 8 hours after a single 5 mg/kg po dose.
分子式
C22H15N3O4Br2
分子量
545.18
CAS号
1191252-49-9
运输条件
Room temperature in continental US; may vary elsewhere.