Mepenzolate bromide - CAS:76-90-4

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Mepenzolate bromide (Synonyms:溴美喷酯；溴化甲哌佐酯)

目录号 : KM18002 CAS No. : 76-90-4 纯度 : 98%

Data Sheet 产品使用指南

Mepenzolate bromide 是一种有效的，具有口服活性的毒蕈碱受体拮抗剂，对 hM2R 和 hM3R 的 K_i 分别为 0.68 和 2.6 nM。Mepenzolate bromide 可用于抑制与肠易激综合征相关的胃肠道过度运动。Mepenzolate bromide 是一种 GPR109A 抑制剂.

规格	价格	是否有货
100mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

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生物活性

Mepenzolate bromide is an orally administered muscarinic receptor antagonist with K_is of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome.Mepenzolate bromide is a GPR109A inhibitor.

体外研究

Mepenzolate not only exerts an anti-inflammatory effect via a muscarinic receptor-independent mechanism, but also a bronchodilatory effect via a muscarinic receptor-dependent mechanism. Mepenzolate is a subtype-non-specific muscarinic antagonist whose bronchodilatory effect and inhibitory effect on intestinal motility can be explained by its antagonistic action on M3R.

体内研究

Mepenzolate bromide, a GPR109A receptor blocker, abolishes the beneficial effects of niacin on body weight, colon wet weight as well as colonic levels of myeloperoxidase (MPO) and VEGF.
Mepenzolate bromide is a muscarinic antagonist. Intratracheal administration or inhalation of Mepenzolate bromide decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction. Mepenzolate bromide may be an effective therapeutic for the treatment of chronic obstructive pulmonary disease (COPD) due to its anti-inflammatory and bronchodilatory activities.

Animal Model:	Adult male Wistar rats, weighing 150-200 g
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection
Result:	Abolished the protective effect of niacin against iodoacetamide-induced rise in colon wet weight as well as the colonic levels of both MPO and VEGF.

Animal Model:	ICR mice (4-6 weeks old, male) and DBA/2 mice (5 weeks old, female)
Dosage:	0.04, 0.38, 3.8, 38 μg/kg; 45.2 and 226 μg per chamber
Administration:	"0.04, 0.38, 3.8, 38 μg/kg administered intratracheally once daily for 14 days 45.2 and 226 μg per chamber by inhalation once daily for 14 days"
Result:	The simultaneous daily intratracheal administration suppressed this enlargement in a dose-dependent manner. The inhalation route was similar to those observed with the intratracheal mode of administration.

分子式

C₂₁H₂₆BrNO₃

分子量

420.34

CAS号

76-90-4

中文名称

溴美喷酯；溴化甲哌佐酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 35 mg/mL (83.27 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3790 mL	11.8951 mL	23.7903 mL
5 mM	0.4758 mL	2.3790 mL	4.7581 mL
10 mM	0.2379 mL	1.1895 mL	2.3790 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器