Galanin Receptor Ligand M35 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM)，也是 galanin receptor 拮抗剂。Galanin Receptor Ligand M35 对人甘丙肽受体 1 型 和 人甘丙肽受体 2 型 的 Ki 值分别为 0.11 nM、2.0 nM。
| 生物活性 |
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively. |
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| 体外研究 |
Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP. |
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| 体内研究 |
Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task.
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| 分子式 |
C107H153N27O26
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| 分子量 |
2233.60
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| CAS号 |
142846-71-7
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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