Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
体外研究
Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line.
体内研究
Alminoprofen (100-300 mg/kg; p.o.) exerts an anti-inflammatory activity.
Animal Model:
Groups of Wistar Rats (Oedema of the paw)
Dosage:
100 mg/kg
Administration:
P.o.
Result:
Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period.
分子式
C13H17NO2
分子量
219.28
CAS号
39718-89-3
运输条件
Room temperature in continental US; may vary elsewhere.