Alminoprofen (Synonyms:EB-382)
目录号 : KM17560 CAS No. : 39718-89-3 纯度 : 98%

Alminoprofen 是苯丙酸类非甾体抗炎药 (NSAID)。Alminoprofen 同时具有抑制分泌磷脂酶A2 (sPLA2) 活性和抗环氧化酶 (COX-2) 的活性。

规格 价格 是否有货 数量
10mg
In-stock
50mg 询价 In-stock
100mg 询价 In-stock

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生物活性

Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.

IC50&Target

sPLA2

 

COX-2

 

体外研究

Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line.

体内研究

Alminoprofen (100-300 mg/kg; p.o.) exerts an anti-inflammatory activity.

Animal Model: Groups of Wistar Rats (Oedema of the paw)
Dosage: 100 mg/kg
Administration: P.o.
Result: Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period.
分子式
C13H17NO2
分子量
219.28
CAS号
39718-89-3
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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计算结果:

工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。