Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
IC50&Target
COX-1
COX-2
体外研究
Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells. Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells.
体内研究
Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice. Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
Animal Model:
DSS-induced acute colitis in C57BL/6 mice
Dosage:
4 mg/kg;16 mg/kg
Administration:
Oral administration; 4 mg/kg/16 mg/kg; 9 days
Result:
Alleviated inflammation in DSS-induced acute colitis.
分子式
C15H13NO3
分子量
255.27
CAS号
52549-17-4
中文名称
普拉洛芬
运输条件
Room temperature in continental US; may vary elsewhere.