KCC2 blocker 1 is an orally active and selective K-Cl cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.
KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats.
Animal Model:
Male Wistar rats
Dosage:
1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis)
Administration:
IV (1 mg/kg) and PO (6 mg/kg)
Result:
Had a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL.
分子式
C22H25NO5S
分子量
415.50
CAS号
1228439-36-8
运输条件
Room temperature in continental US; may vary elsewhere.