MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).
体外研究
MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP).
体内研究
MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively
Animal Model:
Female Sprague-Dawley rats
Dosage:
10 mg/kg
Administration:
P.o. (Pharmacokinetic Analysis)
Result:
The Cmax, AUC0-6 and Tmax were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.
分子式
C50H70N14O19S6
分子量
1363.56
CAS号
1092457-78-7
运输条件
Room temperature in continental US; may vary elsewhere.