Bismuth Subsalicylate (Synonyms:次水杨酸铋; Bismuth oxysalicylate; Bismuth(III salicylate basic))
目录号 : KM16924 CAS No. : 14882-18-9 纯度 : 98%

Bismuth Subsalicylate 是一种有效的口服抗酸和止泻试剂 (anti-diarrheal agent)。Bismuth Subsalicylate 通过抑制体内前列腺素合成 (prostaglandin synthesis),降低胃和肠道黏膜炎症。Bismuth Subsalicylate 广泛用于腹泻疾病的研究,包括消化不良、腹泻、恶心等。

规格 价格 是否有货 数量
500mg
In-stock
5g
In-stock
10g
In-stock
50g 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al.

体内研究

In the gastrointestinal tract, Bismuth Subsalicylate can be converted to salicylic acid and insoluble bismuth salts. Salicylic acid reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H synthase 1/2.
Bismuth Subsalicylate (oral gavage; 100 mg/kg-350 mg/kg) significantly decreases castor oil-induced movement of a charcoal test meal along the small intestine of the mouse and rat and also decreases both the fecal output (dry or wet weight) and the frequency of diarrhea in mice.

分子式
C7H6BiO4
分子量
362.09
CAS号
14882-18-9
中文名称
次水杨酸铋;碱式水杨酸铋;次柳酸铋水杨酸铋;次柳酸铋;亚水杨酸铋
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 1 mg/mL (2.76 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.28 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7617 mL 13.8087 mL 27.6174 mL
5 mM --- --- ---
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

临床试验
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The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
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+
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计算结果:

工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。