CCG-63802 - CAS:620112-78-9

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CCG-63802

目录号 : KM16892 CAS No. : 620112-78-9 纯度 : 98%

Data Sheet 产品使用指南

CCG-63802 是一种选择性，可逆变构的 G 蛋白信号调节子 RGS4 抑制剂。CCG-63802 与 RGS4 特异性结合并阻断 RGS4-Gα_o 相互作用，IC₅₀ 值为 1.9 μM。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gα_o interaction, with an IC₅₀ value of 1.9 μM.

体外研究

CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again.

体内研究

CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling.

Animal Model:	Forty female BALB/c mice aged 6-8 week old
Dosage:	0.05 mg/kg
Administration:	Intratracheal administration; once per week; 90 days
Result:	CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05)

分子式

C₂₆H₁₈N₄O₂S

分子量

450.51

CAS号

620112-78-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 1.67 mg/mL (3.71 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2197 mL	11.0985 mL	22.1971 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

1.

CCG-63802 is dissolved in DMSO and diluted with 0.9% NaCl.

科研文献

•Inflammation. 2018 Dec;41(6):2079-2089.

纯度： 98%

Data Sheet

产品使用指南

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Other Forms of Rapamycin:

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