K-252a - CAS:99533-80-9

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K-252a (Synonyms:SF2370; Antibiotic K 252a; Antibiotic SF 2370)

目录号 : KM16497 CAS No. : 99533-80-9 纯度 : 98%

Data Sheet 产品使用指南

K-252a 是一种十字孢碱类似物，是蛋白激酶的抑制剂，对 PKC、PKA、II型钙调素依赖性激酶和磷酸化酶激酶的 IC₅₀ 值分别为470 nM、140 nM、270 nM和1.7 nM。K-252a 是一种有效抑制 NGF 受体 gp140trk 的酪氨酸蛋白激酶 (TRK) 活性，IC₅₀ 为 3 nM。

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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Kgp-IN-1 hydrochloride In-stock
Ginkgolide A In-stock
Ginkgetin In-stock
VKGILS-NH2 In-stock
7,3',4'-Tri-O-methylluteolin In-stock

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生物活性

K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

体外研究

K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth.

Western Blot Analysis.

Cell Line:	LINC00641-overexpressed cell line.
Concentration:	1.7 nM (NGF (50 ng/mL)).
Incubation Time:	6 h.
Result:	Decreased p-Akt and p-TrkB levels.

Cell Viability Assay.

Cell Line:	PC12 subclone h cells.
Concentration:	3 to 100 nM.
Incubation Time:	8 d.
Result:	Inhibited NGF-promoted neurite outgrowth.

体内研究

K252a (20 mg/kg/day) inhibiting TrkB pathway dampens the neuroprotective effects induced by TH.

Animal Model:	Mice.
Dosage:	20 mg/kg/day.
Administration:	Intraperitoneally, daily, for consecutive 5 days.
Result:	Dampened the neuroprotective effects induced by TH.

分子式

C₂₇H₂₁N₃O₅

分子量

467.47

CAS号

99533-80-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (106.96 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1392 mL	10.6959 mL	21.3917 mL
5 mM	0.4278 mL	2.1392 mL	4.2783 mL
10 mM	0.2139 mL	1.0696 mL	2.1392 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： 98%

Data Sheet

产品使用指南

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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