Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity.
IC50&Target
P-gp
体外研究
Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt.
分子式
C24H30O7
分子量
430.49
CAS号
33676-00-5
运输条件
Room temperature in continental US; may vary elsewhere.