Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.
IC50&Target
soluble guanylate cyclase
体外研究
Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings.
Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells.
Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol.
分子式
C21H19N3O6S3Cl2
分子量
576.49
CAS号
254877-67-3
运输条件
Room temperature in continental US; may vary elsewhere.