Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist, with anti-myopia effect. Atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias.
体外研究
Atropine increases cAMP independently of M1/2/3-muscarinic receptors in cardiomyocytes.
Atropine inhibits the cAMP-specific phosphodiesterase PDE4 in cardiomyocytes.
Atropine might inhibit myopia via α2A-adrenoceptors, , instead of through the mAChR M4/cM4 receptor subtype.
体内研究
Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4 (PDE4).
Atropine (30-60 mg/kg/day; s.c.) causes changes in mouse motility that is not correlates to its modification of ACh levels in the CNS.
Animal Model:
Female albino Swiss Morini mice (20-25 g)
Dosage:
30 mg/kg, 40 mg/kg, 60 mg/kg
Administration:
Subcutaneous injection; daily
Result:
Chronic administration of atropine caused significant increase of motility at doses which caused no modification of ACh levels.
分子式
C17H23NO3
分子量
289.37
CAS号
51-55-8
中文名称
阿托品;阿妥品;阿托平;阿脱品
运输条件
Room temperature in continental US; may vary elsewhere.