Levocabastine hydrochloride (R 50547) 是一种具有抗过敏活性的长效、高效、选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型2 (NTR2) 拮抗剂，对 mNTR2 的 Ki 值为 17 nM。
| 生物活性 |
Levocabastine (R 50547) hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究 |
Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan.
|
|||||||||
| 分子式 |
C26H30ClFN2O2
|
|||||||||
| 分子量 |
456.98
|
|||||||||
| CAS号 |
79547-78-7
|
|||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
|||||||||
| 储存方式 |
|
|||||||||
| 临床试验 |
|
纯度： ≥98%
关注我们
获得KKL MED 最新资讯
咨询热线：
400-881-9290
Data Sheet