p-Ethynylphenylalanine (Synonyms:4-Ethynyl-L-phenylalanine)
目录号 : KM15812 CAS No. : 278605-15-5 纯度 : 98%

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的,可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其 Ki 值为 32.6 μM。

规格 价格 是否有货 数量
50mg
In-stock
100mg 询价 In-stock
200mg 询价 In-stock

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生物活性

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.

体外研究

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7).

体内研究

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.

Animal Model: Male Sprague-Dawley rats (200 g)
Dosage: 30 mg/kg
Administration: Intraperitoneal injection
Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
分子式
C11H11NO2
分子量
189.21
CAS号
278605-15-5
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

1M HCl : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 1 with HCl)

1M NaOH : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 2.22 mg/mL (11.73 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2851 mL 26.4257 mL 52.8513 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL
10 mM 0.5285 mL 2.6426 mL 5.2851 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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