Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
体外研究
Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.
Antagonist G activates JNK1 in SCLC cells.
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.
Cell Viability Assay
Cell Line:
SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.
Concentration:
0-100 μM.
Incubation Time:
24 h.
Result:
Inhibited cell growh.
分子式
C49H66N12O6S
分子量
951.19
CAS号
115150-59-9
运输条件
Room temperature in continental US; may vary elsewhere.