Ambroxol hydrochloride - CAS:23828-92-4

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Ambroxol hydrochloride (Synonyms:NA-872 hydrochloride)

目录号 : KM15422 CAS No. : 23828-92-4 纯度 : ≥98%

Data Sheet 产品使用指南

Ambroxol hydrochloride (NA-872 hydrochloride) 是前药溴己辛的活性代谢产物，具有强效祛痰作用。Ambroxol hydrochloride 是一种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性。Ambroxol hydrochloride 可诱导肺自噬，并有用于帕金森氏病和神经性戈谢病研究的潜力。

规格	价格	是否有货
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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Other Forms of Rapamycin:

Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

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生物活性

Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.

体内研究

Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.

分子式

C₁₃H₁₉Br₂ClN₂O

分子量

414.56

CAS号

23828-92-4

中文名称

盐酸氨溴索

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 8.33 mg/mL (20.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4122 mL	12.0610 mL	24.1220 mL
5 mM	0.4824 mL	2.4122 mL	4.8244 mL
10 mM	0.2412 mL	1.2061 mL	2.4122 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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