Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.
Target: Others
tetrabenazine (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. TBZ is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. In contrast to typical neuroleptics, TBZ has not been demonstrated to cause tardive dyskinesia [1, 2]. Twenty patients with tardive dyskinesia (mean duration = 43.7 months) were videotaped before and after tetrabenazine treatment. One patient did not tolerate tetrabenazine owing to sedation. The remaining 19 were rated after a mean of 20.3 weeks at a mean tetrabenazine dose of 57.9 mg/day. There were significant improvements in mean scores on both the patient AIMS self-rating and the AIMS motor subset evaluated by the blind videotape raters. All 19 patients continued to take tetrabenazine after the study [3].
分子式
C19H27NO3
分子量
317.42
CAS号
58-46-8
中文名称
丁苯那嗪;丁苯喹嗪;特苯那嗪;四苯喹嗪
运输条件
Room temperature in continental US; may vary elsewhere.